The fall of Tenochtitlan—the island capital of the Mexica (Aztec) Empire—and its aftermath remains one of the most significant moments in world history and one of its most widely debated. This year marks the 500th anniversary of the arrival of Spanish explorers to the coasts of Mexico. To commemorate the occasion, the History Major Seminar, a capstone research course for history majors at Texas Christian University, annotated a digital copy of the 1550 Uppsala Map, one of the region's earliest visual representations of life after the downfall of the Aztecs. Drawing from the Latin American Collection, a specialized corpus of rare books, manuscripts, and broadsides made in the New World housed in TCU Special Collections, each annotation details aspects of government, trade, health, disease, culture, religion, education, ecology, and human-animal relations.